Eric Sykes and Hattie Jacques play twins living together at 24 Sebeastapol Terrace. Each episode was titled Sykes And A... - the theme of the episode completed the title.

Along with their snobbish neighbour Mr Brown, they find themselves in many unlikely and uproarious situations, often with Eric's almost child-like behaviour largely as the root cause.

During Series 3 Mr Brown emigrated to Australia.