Further credits include writing for Spencer Jones's upcoming Deep Fake Neighbour Wars on ITVX and Sky's paramedic sitcom Bloods. And she shot her feature film acting debut in Cottontail last year, appearing alongside Ciaran Hinds, Lily Franky and Ryo Nishikido.
Beginning stand-up at 37, the former secondary school English teacher and mother-of-three was recently diagnosed with breast cancer.
"I didn't go back to work in September, I found a lump ... we're just over a year since my diagnosis" Smyth told fellow comic Cally Beaton on her Namaste Motherf**kers podcast, released on Thursday.
"I submitted my sitcom to the BBC the same day I went to the GP about my boob. I got feedback and notes the same day I went in for my mastectomy ... I did Live At The Apollo, pretty much to the day of finding my lump. These wonderful, awesome parallels.
"Darkest days of chemo I pictured stepping out to the Live At The Apollo stage, to the point that me and my agent laughed, because I found out I didn't get it. Then a week later, I found out I did get it because someone pulled out or something. She said: 'You didn't get it". And I went, 'that don't feel right!'".