A seven-part series has been ordered by the corporation, and is expected to be ready to broadcast during 2016.
However, following approval of the decision to shut down BBC Three as a television channel in February, the series will be published first on iPlayer. It is expected to gain a late-night BBC One slot at a later date.
The follows 30-something loser Andy and his growing bond and friendship with teenage nephew Errol, against the backdrop of his sister - Errol's mother - working to re-establish her own life after a divorce, and Andy struggling with his own lack of professional prospects.
Star Nick Helm says: "Uncle is more than a show about an unconventional family unit. The whole production is like a family, from Russell on sound and Terry on Rocky Road duties, to Ali producing and keeping everything ticking like clockwork, Oli and Lilah who write and direct the show and music videos, and Daisy and Elliot who, whilst playing my fake TV family, end up substituting my actual family for seven weeks a year. I'm really looking forward to seeing what the new series has got in store and getting the 'Family' back together again."
Shane Allen, BBC Controller, Comedy Commissioning, adds: "Great to welcome back TV's unlikeliest double-act for another blend of the funny and the poignant."
Producer Alison MacPhail from Baby Cow Productions says: "We're thrilled to be working with [writers] Oliver Refson and Lilah Vandenburgh again, and very much look forward to our next family outing with Nick Helm, Daisy Haggard and Elliot Speller-Gillott. It really is as much fun as it looks working on this show, and we are delighted to have a third series commissioned."