Tired of being the little assistant, Alex Horne finally has the chance to pitch his very own TV show to Channel 4. Having been granted permission by Greg Davies, Alex wants to be the leading man of a new late-night music chat show, The Horne Section TV Show, filmed live from his family home. With the help of his loyal and much more talented band, The Horne Section, the group do their best to impress the big bosses at Channel 4.

Luckily for them, Alex's wife's friend Thora (Desiree Burch) takes pity on them, stepping in at the last minute as the show's reluctant producer. With her help, they make it to air, despite Channel 4 exec Ash (Georgia Tennant) being generally obstructive, novice TV researcher Lucy (Camille Ucan) looking at her phone, flustered intern runner Nelly (Tim Mahendran) attempting to levitate, and John Oliver being the only person desperate to be on the show.

Hoping to make it a series to remember, they set the stage for special guest appearances from Martin Kemp, Big Zuu, Imogen Heap, Anneka Rice and Dr Ranj Singh, who join Alex and The Horne Section for this unruly, ridiculous and surprisingly satisfying show.