- Simon Pegg, Andy Serkis, Isla Fisher, Tom Wilkinson, Jessica Hynes, Bill Bailey, Hugh Bonneville, Allan Corduner and others
- Piers Ashworth and Nick Moorcroft
- John Landis
- Barnaby Thompson and Alexandra Ferguson
It is the early 19th Century and, with a world-renowned reputation as a centre of medical excellence, Edinburgh's educational establishments are running short of corpses to dissect.
Hard-up Irish couple William and Lucky Hare, and fellow countryman and friend William Burke, stumble across a useful source of income when one of their tenants dies suddenly: having failed to dispose of the body by other means, they discover the medical community's need for fresh corpses - and so begins a search for more cadavers.
Initially attempting grave-robbery, after another tenant falls gravely ill the pair soon take matters into their own hands...