Two misfits struggle to survive in the lurid world of FILTH, a weekly lads' mag. Rob (James Buckley) has a knack for lads' mag writing, but the job threatens his chances of ever having a relationship. Mike (Danny Morgan) couldn't be less suited to the job: he's naive, sensitive and a virgin, but eager to learn.

They are minnows in a testosterone pond, ruled over by Chad (Danny Dyer), an ex-military uber-lad, and Michelle (Tracy-Ann Oberman), their ball-busting editor, who embodies the magazine better than any man in the place.