The series will star Smith in the titular role of anxiety and depression sufferer Rosie Molloy, following her and her family as she attempts to pursue a life free of addictions to alcohol, tobacco, food, sex, and much stronger narcotic substances alike.
A workaholic with a senior career in a high-end accountancy firm, Rosie is seen striving to recover from a spiral of self-destruction brought about by her relentless over-achieving and high-stress workload.
Susan Nickson has written the comedy having consulted extensively with a number of mental health professionals.
British Comedy Guide understands that the series was picked up off the strength of a pilot script, filming of which was cancelled amidst the effects of both the coronavirus pandemic and Smith falling pregnant. She gave birth to her first child, Billy, in May 2020.
Filming for the two series begins on location in Manchester shortly, with the first run expected to air later in 2022.
In recent years the actor has featured in a number of acclaimed stage roles, including a long run as central character Elle Woods in the stage adaptation of Hollywood hit Legally Blonde, the eponymous role in Hedda Gabler at The Old Vic, and the Narrator in 2019's hit London Palladium revival of Joseph And The Amazing Technicolor Dreamcoat. She was most recently seen on screen in BBC drama Four Lives.
Appointed an OBE in the 2015 New Year Honours for her acting work, Smith has also won two prestigious Olivier Awards, a BAFTA and a National Television Award, amongst others.
Her other comedy credits include Inside No. 9, Gavin & Stacey, The More You Ignore Me, Jonathan Creek and a string of David Walliams's Christmas specials, most recently 2020's Jack And The Beanstalk: After Ever After.
Sky has not responded to British Comedy Guide's request for comment.