Following months of rumour, the corporation has now confirmed to trade magazine Broadcast that it is talking to the Scottish comedian with a view to creating a brand new series for him.
The comic was last seen on Channel 4 in December 2010, when his sketch show Frankie Boyle's Tramadol Nights attracted much controversy and many column inches from fans and critics alike, particularly in relation to a joke which referred to the disabled son of glamour model turned TV personality Katie Price (aka Jordan).
A spokeswoman for Channel 4 said: "Tramadol Nights was a creative one-off series for Frankie Boyle. C4 and Frankie are working together on a new comedy vehicle with a topical focus. Hopefully a new pilot will record later in the year but it is still very much a work in progress."
The new show is in early development stages and details are scarce, but it is expected to be recorded in front of a studio audience. It is believed it will not be produced by The Comedy Unit, the Glasgow production company behind Tramadol Nights.