Each episode of the show will sees two contestants compete for a prize which has been specially selected for them. Helping the contestants find the answers will be five famous faces from the worlds of sport, music, TV or film. Additionally, along the way, the host will ensure that the celebrity guests "take on one or two unexpected questions of their own".
Andy Culpin, from production company 12 Yard, comments: "We are so excited to be working with a talent as big as Rob Brydon on this new Saturday night series. His hilarious interaction with the famous faces and members of the public takes the show to another level."
Contestants are currently being sought for The Guess List. To get an application form email firstname.lastname@example.org. The closing date for applications is the 24th February 2014.
Rob Brydon hosted three series of The Rob Brydon Show (pictured) on BBC Two, but the show was axed after the 2012 series, reportedly due to falling ratings. Speaking at the time, the BBC said it was keen to find a new vehicle for the Welsh comedy star.
BBC One has been struggling to find a light entertainment format for its Saturday evening schedule. Recent attempts, including Lee Mack's All Star Cast, That Puppet Game Show and I Love My Country, have all failed to win big audiences and been cancelled after just one series.
Rob Brydon is shortly set to sit in the host's chair again as another series of the hit panel show Would I Lie To You? is recorded for BBC One. He will also return alongside Steve Coogan in a second series of their part-improvised sitcom The Trip To Italy, for BBC Two.