The broadcaster said today: "Sketch shows have been a mainstay of British TV comedy, well for just about forever. But despite the longevity and familiarity of the genre, every now and again, a sketch show comes along that manages to feel fresh, different and - crucially - funny, all at the same time - Cardinal Burns was that show, with their roll call of brilliantly conceived characters and finely-honed comic writing."
Ratings for the E4 broadcasts were not high, but the comedy developed a cult following and has won several awards. It has also been nominated for a BAFTA Television Award, the results of which will be revealed on Sunday.
Cardinal and Demri-Burns say: "We're delighted to be given a second series - the response to the first series was slightly overwhelming. The fact that the series has moved to Channel 4 is just amazing and we're thrilled to be collaborating with Brian Eno on our tricky second series."
Channel 4's Comedy Commissioning Editor, Rachel Springett, who ordered the second series, said: "We are thrilled to have commissioned a second series of the multi award winning sketch show Cardinal Burns. We are delighted to bring to Channel 4 the likes of Banksy and The Office Flirt with a host of new brilliantly crafted and original characters including airline pilots Malcolm and Geoff and rapper Curtis Blow."
Jenna Jones, Executive Producer for production company Left Bank Pictures, added: "I am thrilled that Cardinal Burns is returning for a second series, and excited that it will be launching on Channel 4. This bold re-commission is testament to Channel 4's commitment to original talent and their ambition to bring Seb and Dustin's unique comic brilliance to a wider audience."
The following clip features the duo's Office Flirting sketch.