Having run since 2010, the event attracts the biggest names from the comedy world to both host and perform. This year's show will be held on Saturday 18th May, with a special 2 hour TV edit broadcast on Channel 4 shortly thereafter.
Guests so far confirmed for this year's show include: Adam Hills, Alan Carr, Jack Dee, Jason Byrne, Jo Brand, Jonathan Ross, Josh Widdicombe, Kevin Bridges, Lee Evans, Michael McIntyre, Noel Fielding, Paddy McGuinness, Paul Chowdhry, Rhod Gilbert, Rich Hall, Seann Walsh and Tom Stade.
Tickets will be available to purchase at 10am on Friday morning (8th March), ranging in price from £40 to £100 each. Money raised from ticket and DVD sales will fund a brand new operating theatre at the world famous specialist hospital, treating some of the UK's - and the world's - sickest and most seriously ill children, often suffering rare and complicated medical conditions.
The following video is a short highlights package from the first Gala, held in 2010.
Sorry, this video clip is no longer available.