The (fictional) teaching hospital, St Swithin's, is the location of this medical sitcom. The action follows junior doctor Michael Upton, an earnest type but easily led astray by his colleagues, the laddish Waring and Collier and the smooth wastrel Stuart-Clark.

The recurring theme of this series (and indeed most of the succeeding series) was the clash between the keen interns and their intimidating superior Professor Loftus, a fearsome man.