The half-hour episode will be themed around Brexit, with the episode - titled Little Brexit - set to be broadcast this Thursday (31 October) at 6:30pm, the day the UK may leave the EU.
The episode was recorded in front of an audience at the BBC Radio Theatre. The project has been a closely guarded secret, with tickets for the show not mentioning the stars, and the title given on tickets and in the radio schedules as The All-Star Brexit Comedy Show.
Radio 4 says: "The programme will catch-up with many of Matt and David's much-loved characters to see how the hottest topic of modern British history is affecting their lives. Characters we'll be hearing from include Dafydd, Vicky Pollard, Emily Howard, Marjorie Dawes, Mr Mann, and Lou and Andy."
Sioned Wiliam, the commissioning dditor for Radio 4 comedy, says: "Matt Lucas and David Walliams are uniquely talented writers and performers as well as one of the UK's most loved comedy duos. It's a privilege to have them back on Radio 4, where Little Britain first began almost 20 years ago."
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