The duo will pair up to host the new comedy show on Radio X which will air every Sunday from 8am - 11am, starting this Sunday 9th June.
The news comes following the departure of long-time Radio X hosts Elis James and John Robins to 5 Live.
Actor and comedian Matthew Crosby, who is also part of sketch group Pappy's, says: "I've always wanted to know what 8am on a Sunday looks like, and what better place to find out than the studios of Radio X? I cannot wait for Ed and I to demonstrate the '3 Golden Cs' of broadcasting: Chatting, Chuckling and Churning out the hits."
Mock The Week star Ed Gamble adds: "Although I agreed to this under the misapprehension that it was 8pm and not 8am, I'm still very excited to start doing a show on Radio X with Matthew. Providing he doesn't run with his stupid idea about the '3 Golden Cs'."
Radio X's Managing Editor Matt Deverson comments: "Ed Gamble and Matthew Crosby are renowned for their sharp, witty humour and it's hugely exciting to bring these two exceptionally talented comedians together for a show which will become a true appointment to listen on Radio X. With the addition of Ed and Matthew's brand new show, Radio X listeners can look forward to a superb comedy offering - as well as the biggest indie and rock tunes - on Sunday mornings with Danny Wallace also on the schedule. We're thrilled to have them on the team as we carry on the X brand's long-standing heritage in comedy on the radio."
Listen to Ed Gamble & Matthew Crosby on Radio X on Sundays, 8am - 11am. Radio X is on 104.9 FM in London, 97.7 FM in Manchester and on digital radio across the UK. You can also listen on mobile via the Radio X app and the Global Player, via radiox.co.uk, and on smart speakers.