The Carmarthen-born stand-up and broadcaster has hosted the Saturday morning show on the station since 2006.
Rhod Gilbert says: "Despite what I say on air, I love doing the show on Radio Wales on a Saturday. But having returned to stand-up, and with such a busy live touring schedule this year, it's proving impossible. I am never there, and it's getting embarrassing, so I am standing aside, with immediate effect.
"I'd love to come back and do some one-off specials on Radio Wales in the future though, if they will have me, and I know that 'person in her own right' Sian, and 'dog in her own right' Rhosie, feel the same way.
"So, after so many happy/miserable/disappointing/tedious (delete as applicable) years on the station, with regret, I'm out. For now. But watch this space. Thanks for listening my dear listeners; it has been a chaotic ball."
Rhod will bow out with a special live show recorded at the Machynlleth Comedy Festival on Saturday May 4th.
BBC Radio Wales editor Colin Paterson says: "Rhod is one of the standout comedy voices of his generation and we're grateful to him for making us laugh every week. He's been a big part of Radio Wales for over ten years; I hope he'll be back with us very soon."
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