The comedians, who have been married since 2009, are set to make six hour-long episodes later this year.
Channel 5 says: "The series will follow comic couple Paul Merton and Suki Webster as they immerse themselves completely in the incredible world of motorhoming bringing the audience the ultimate A-Z guide to having an epic Great British Adventure, on four wheels.
"With a record jump in motorhome and campervan sales in 2020, Paul and Suki will be exploring all there is to know about this increasingly popular way of travelling by hitting the road in their very own motorhome. In each episode they'll be driving through some of the most beautiful parts of Britain, discovering hidden treasures along the way and each night rocking up at a glorious motorhoming hot spot to put on the brakes and put up their feet, in their home away from home on wheels.
"Brits remain the biggest buyers of motorhomes in Europe and with so many available on the market, Paul and Suki will showcase and review the latest models, from top of the range, best buys and most popular.
"On their travels they'll be taking in the sights, tasting local delicacies, meeting fellow motorhoming enthusiasts and sharing with us a host of surprising caravanning hacks and secrets; including how to make your caravan warmer, which loo is the comfiest, how to choose the best spot in a caravan park and how to park it, plus reviews of gadgets available that will change your travels forever, making your next trip unforgettable."
Paul Merton and Suki Webster met as part of the Impro Chums comedy group. They've also made the Radio 4 comedy dramas My Obsession together. Talking about their new show, they say: "Having performed live comedy together for many years in an atmosphere of beautiful magical harmony we are thrilled to bring our insincere relationship to TV via Channel 5."
This new commission comes following the recent success of Million Pound Motorhomes on Channel 5. Broadcast in February, it saw Channel 5 boost viewers to its 8pm slot by 28%, with 1.5 million tuning in.
Commissioner Kit Morey comments: "Paul is one of the nation's best loved performers and I'm incredibly excited to welcome both him and Suki to Channel 5. As the country begins to open up and plan for their summer holidays, what better way to explore Britain than on four wheels with a SUPER comfy King-Sized bed in the back of your motor! This series will give a fascinating insight into a unique way to travel and I'm looking forward to seeing Paul bring his distinctive comedy and humour to the wonderful world of motorhoming."
Charlie Bunce from production company Curve Media, adds: "There cannot be a better way to close the lid on the last year than by hitting the road in a motorhome with Paul and Suki. It will be a chance to visit wonderful bits of Britain, and test out the very best campervanning super hacks and must have gadgets. Paul and Suki's humour will be the perfect kickstart to the summer for Channel 5 viewers."
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