Me, Myself & Her is a comedy series about the funniest thing of all, depression. Mia is a normal millennial with a seemingly normal life; a job, a steady boyfriend and friends. She's content with life until one day she finds an unwanted guest in her kitchen, Depression.

Depression refuses to leave and delights in nothing more than causing chaos in Mia's life. Worst of all only Mia can see her and Depression has a talent of turning up at the worst time.?