Michael McIntyre leads the list with four nominations: Funniest Man, Funniest Show On TV, Funniest DVD and Best Stand-Up. Meanwhile the return of Shooting Stars earlier in the year sees the wacky panel show re-appearing in the Funniest Panel Show category, and Vic and Bob gaining a nomination for Funniest Double Act.
A number of new categories have also been added this year, including the Funniest Radio Sidekick category and Funniest Twitterer.
Here's the full list of nominations for the Loaded LAFTAS 2010:
Funniest Radio Sidekick
Aled Jones (Radio 1 - Chris Moyles Show)
Beccy Huxtable (Radio 1 - Scott Mills Show)
Brian Murphy (Absolute Radio - Christian O'Connell Show)
'Comedy' Dave Vitty (Radio 1 - Chris Moyles Show)
Charlie Hedges (Kiss 100 London - Rickie and Melvin Breakfast Show)
Comedy fans can log onto loaded.co.uk to vote for their favourites. Voting closes 20th January.
The results will be announced at an awards ceremony at the The Cuckoo Club in London on Wednesday 27th January from 12pm. The ceremony will be hosted by Olivia Lee.
The 2010 LAFTAS will be the 7th year Loaded has run the awards. This year the awards are sponsored by Durex Ora - a social networking site for Durex enthusiasts (no, really!)
Loaded Editor Martin Daubney comments: "I'm more excited about this year's awards than ever before. The list of nominations shows how incredibly diverse British comedy has become, across live stand up, television, radio and film. As usual, I am hoping that the event in January will be as raucous as ever."