As Dilbert has not been mentioned in this thread yet, I much preferred the Barry McKenzie strips. But Dilbert was brilliant for its first decade before some uninspired staleness started to emerge.
Further to a point on a non-comics/cartoons thread, Dilbert creator Scott Adams had to make the jump from pen and ink to a tablet because he suffers from a sore-paw condition called focal dystonia. As he recounts in his succinctly titled book, How to Fail at Almost Everything and Still Win Big: Kind of the Story of My Life:
"By the early nineties, Dilbert was a modest success, but it was nowhere near the point where I was tempted to quit my day job at the phone company, Pacific Bell. I would wake at 4:00 A.M. to draw before my commute, then work all day in my cubicle prison and come home to draw all night. My time windows for drawing were always compressed, which put a lot of pressure on my drawing hand. The overuse took its toll, and my pinkie finger started to spasm whenever I touched pen to paper, making it nearly impossible to draw...
... I met with the doctor and he diagnosed me in minutes. I had something called a focal dystonia, common to people who do repetitive tasks with their hands, primarily musicians, draftsmen, and that sort of job. It wasn't carpal tunnel. This was different.
"What's the cure?" I asked.
"Change jobs," he said. "There's no known treatment."
I walked out of the doctor's office with my life demolished. My dream of being a cartoonist for the rest of my life was over unless I found a way to be the first person in the world to beat a focal dystonia.
What were the odds of that? ...
... I went back to drawing right-handed, paced myself, and didn't have a problem again for years. My hand doctor said I'm part of the literature on this topic now, although my name is not mentioned.
In 2004, after once again doing too much drawing in a compressed time, the dystonia returned. This time I tried a smarter work-around. I made an educated guess that somewhere in the world a company was probably making a computer tablet or screen on which I could draw my comic. My hypothesis was that drawing on a computer would feel different enough from pen on paper that the dystonia wouldn't trigger, even though I would be drawing with a stylus just as I would with a pen.
I did some Google searches and discovered that Wacom was making a special computer monitor for artists. I ordered it the same day. In a week it was up and running. As I'd hoped, drawing on the computer was different enough that the dystonia didn't trigger. And through my not reinforcing the trigger and the spasm, the dystonia faded away. I'm sure it would come back if I tried drawing or writing on paper for a long time, but since that will never happen, it's a nonissue in my life.
By the way, drawing on the Wacom product cut my total workday in half. The focal dystonia was a case of extraordinary bad luck for a cartoonist. But when I got done beating the dystonia problem to death and rifling through its pockets, I came out the other end a far more efficient cartoonist. The quality of my drawing improved dramatically on the Wacom because it's so easy to make small adjustments. On balance, I came out way ahead."