Rosie Dunne and her best friend Alex have been best friends since age six. Just as they're discovering the joys of teenage nights on the town, they're also discovering dating disasters. As they dream of travelling the world and new adventures, they decide to take a leap of faith, both on life and on each other, and leave their small British town for Boston together to attend university. But fate has other plans, as Rosie discovers that her crazy night out with the most popular boy in school has left her pregnant. She encourages Alex to go to America without her, hopeful that she'll catch up with him soon.

Over the next twelve years, their lives change in all kinds of ways, both expected and unexpected. There are new experiences, new relationships, and all of the other ups and downs that life brings. Their undeniable connection remains, but can their friendship survive the years and miles? And at the back of Rosie's mind is whether they were meant to be more than just good friends all along. Misunderstandings, circumstances and sheer bad luck have kept them out of each other's arms, but when presented with the ultimate opportunity, will they gamble everything for the chance to be together at last?

Based on the bestselling novel Where Rainbows End, Love, Rosie is Cecelia Ahern's follow-up to her box-office hit P.S. I Love You.