Fanged Up follows the story of cock-sure, wannabe-playboy, Jimmy Ragsdale, who may have the gift of the gab, but certainly doesn't have the lifestyle he wants. After a desperate play for the ladies, in one foul swoop, Jimmy gets himself fired and arrested. He's sent to the mysterious Stokesville prison, where he's due to stay on remand over the weekend until his hearing. However, he soon realises he's not going anywhere, trapped in an eerie prison that's home to a big secret.

He's arrived on the night that an ancient ceremony will take place, allowing the Governor and his staff completing their metamorphosis into vampires, and the inmates are due to become their first meal Jimmy and his newfound comrades - including the prison doctor, his ex-girlfriend, Katie Makepeace - must work together to find out how to stop Governor Payne and the warden, Ms. Renfield from keeping them trapped in their vampiriclarder.