| Steve Coogan |
Steve Coogan - Tristram Shandy & Walter Shandy |
| Rob Brydon |
Rob Brydon - Toby Shandy |
| Keeley Hawes |
Elizabeth |
| Shirley Henderson |
Susannah |
| Dylan Moran |
Dr Slop |
| David Walliams |
Parson |
| Jeremy Northam |
Mark |
| Benedict Wong |
Ed |
| Naomie Harris |
Jennie |
| Kelly Macdonald |
Jenny |
| Elizabeth Berrington |
Debbie |
| Mark Williams |
Ingoldsby |
| Kieran O'Brien |
Gary |
| Roger Allam |
Adrian |
| James Fleet |
Simon |
| Ian Hart |
Joe |
| Ronni Ancona |
Anita |
| Greg Wise |
Greg |
| Stephen Fry |
Patrick Curator & Parson Yorick |
| Gillian Anderson |
Gillian Anderson - Widow Wadman |
| Raymond Waring |
Trim |
| Conal Murphy |
Young Tristram Shandy (6) |
| Joe Williams |
Young Tristram Shandy (9) |
| Paul Kynman |
Obadiah |
| Mark Tandy |
London Doctor |
| Mary Healey |
Midwife |
| Jack Shepherd |
Surgeon |
| Claire Keelan |
Make Up Assistant |
| Mark Hadfield |
Leo |
| Jenny Ogilvie |
Sandy |
| Anthony H Wilson |
TV Interviewer |
| Justine Mitchell |
Tony's Director |
| Ashley Jensen |
Lindsey |
| Paul Rider |
Prop Guy |
| Sara Stewart |
Joanna |
| Stephen Rodrick |
New York Times Reporter |
| Stuart Wilson |
Sound Mixer |
| Rosie Cavaliero |
Rachel |